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3 edition of Identification and characterization of TRF1 found in the catalog.

Identification and characterization of TRF1

Douglas Gordon McNeel

Identification and characterization of TRF1

a DNA-binding protein in a yeast linear DNA plasmid system

by Douglas Gordon McNeel

  • 305 Want to read
  • 31 Currently reading

Published .
Written in English

    Subjects:
  • Protein binding.,
  • Yeast.,
  • DNA polymerases.,
  • Plasmids.

  • Edition Notes

    Statementby Douglas Gordon McNeel.
    Classifications
    LC ClassificationsMicrofilm 94/2279 (Q)
    The Physical Object
    FormatMicroform
    Paginationx, 146 leaves
    Number of Pages146
    ID Numbers
    Open LibraryOL1241883M
    LC Control Number94628637

    Shastri et al. have identified new classes of difficult-to-replicate sequences in the mouse and human genomes that are highly dependent on ATR function for stability during DNA replication. Structure-forming short tandem repeats, inverted retroelements, and quasi-palindromic AT-rich repeats characterize the sites for fork collapse caused by ATR by: Role of TRF1 in cancer resistance in a longest-lived rodent. talk. Autexier, Chantal. Regulation of telomerase RNA-dyskerin interactions by SUMOylation. talk. Aviv, Abraham. Transgenerational telomere length dynamics in humans—The roles of paternal age at conception and cancer. talk. Azarm, Kameron.

    For my thesis project, which has just been published in Biochemistry, I performed an in vitro characterization of functional interactions between TRF1, TRF2 and Rad51 recombinase.   Pin2 is identical in sequence to TRF1, except for an internal deletion of 20 amino acids, suggesting that these two proteins may be derived from the same gene, PIN2/TRF1 (Shen et al., ). The Pin2-interacting protein PinX1 was shown to bind the telomerase catalytic subunit hTERT and to potently inhibit its activity (Zhou and Lu, ).Cited by:

    DETECTION AND MOLECULAR CHARACTERIZATION OF Pepper mild mottle virus IN SERBIA 1. _____ Corresponding author: Dragana Milošević, Institute of Field and Vegetable Crops, Makima Gor Novi Sad, Serbia, phone:+ 21 , fax:+ , E-mail: [email protected] UDC DOI: /GENSRM Original scientific .   This issue of Current Biology features five reviews covering various key aspects of the eukaryotic cell cycle. The topics include initiation of chromosome replication, assembly of the mitotic spindle, cytokinesis, the regulation of cell-cycle progression, and cell-cycle modeling, focusing mainly on budding yeast, fission yeast and animal cell model systems.


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Identification and characterization of TRF1 by Douglas Gordon McNeel Download PDF EPUB FB2

The human TERF1 gene is located in the chromosome 8 at 73, bp. Two transcripts of this gene are alternatively spliced products. The TERF1 gene is also known as TRF, PIN2 (Proteinase Inhibitor 2), TRF1, t-TRF1 and h-TRF1-AS. ProteinAliases: TERF1, PIN2, TRBF1, TRF, TRF1, hTRF1-AS.

Production of Pin2, t-TRF1, and t-Pin2 fused to EGFP in the CEM and T98G cell lines. Scale bars: 10 μm. A: Telomeric localization of EGFP-Pin2 and EGFP-t-TRF1, but not EGFP, in CEM The human telomeric repeat binding factor protein (TRF1) is shown to be important in regulating telomere length.

However, nothing is known about its function and regulation during the cell cycle. @article{osti_, title = {Characterization of the telomere complex, TERF1 and TERF2 genes in muntjac species with fusion karyotypes}, author = {Hartmann, Nils and Scherthan, Harry}, abstractNote = {The telomere binding proteins TRF1 and TRF2 maintain and protect chromosome ends and confer karyotypic stability.

Chromosome evolution in the genus Muntiacus is characterized by numerous. Ensembl ENSG ENSMUSG UniProt Q9C0C2 P RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr – Mb Chr 2: – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse kDa tankyrasebinding protein is an enzyme that in humans is encoded by the Aliases: TNKS1BP1, TAB, tankyrase 1 binding protein 1.

BRCA1 overexpression caused shortening of telomeres in several cancer cell lines, independent of telomerase activity. Another study showed that BRCA1 knockdown lead to chromosomal instability due to telomere dysfunction.

BRCA1 was shown to be bound to telomeres through interactions with TRF1 and TRF2 mediated by RADCited by: 7. @article{osti_, title = {Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts}, author = {Michailidis, Georgios and Saretzki, Gabriele and Hall, Judith}, abstractNote = {In this study, we compared the endogenous expression of genes encoding telomere regulating proteins in cultured chicken embryonic fibroblasts (CEFs) and day-old chicken.

Characterization of telomeric repeat-containing RNA (TERRA) transcripts during mouse early embryo development. poster. Wang, Hong.

TIN2 is an architectural protein stabilizing TRF1-mediated telomeric DNA-DNA pairing at the single-molecule level. talk. Wong, Judy. The first-stage MS spectrum was used to generate a list of targets for direct MS n analysis using the second instrument, vMALDI-LTQ. An LTQ mass spectrometer is an extremely fast and efficient device for acquisition of MS n data.Peaks meeting user-defined criteria are automatically extracted to a text file; this file is used to generate an instrument control script to automate acquisition Cited by: Our investigation of interdependencies between DNA repair and telomeres will ultimately lead to identification and characterization of previously unappreciated telomere dysfunction, which in turn will provide a useful indication of an underlying repair defect.

For example, TRF1 and TRF2 have multiple interacting binding partners, including. However, recent identification of Tbf1p, a novel telomere repeat binding factor, in Schizosaccharomyces pombe, in which only Taz1p had been described as a TRF1/TRF2 orthologue, indicates that two TRF1/TRF2 orthologues are conserved between fission yeast and mammals (Pitt et al., ).

The v-myb avian myeloblastosis viral oncogene homolog (MYB) superfamily constitutes one of the most abundant groups of transcription factors (TFs) described in plants. To date, little is known about the MYB genes in Rehmannia glutinosa. Forty unique MYB genes with full-length cDNA sequences were isolated.

These 40 genes were grouped into five categories, one R1R2R3-MYB, four TRFL MYBs, four Cited by: Introduction.

Since the discovery of epidermal stem cells nearly 40 years ago [], the identification of epidermal and keratinocyte stem-like populations has been of great interest, due to their potential applications for wound healing and the treatment of epithelial ly, the identification, characterization, and utilization of keratinocyte stem cells (KSCs) from human oral Author: Mo K.

Kang, Shebli Mehrazarin, No-Hee Park. TATA-box-binding protein (TBP) is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of the preinitiation complex.

Two proteins with high homology to TBP have been found: TBP-related factor 1 (TRF1), described only in Drosophila melanogaster, and TRF2, which is broadly distributed in by: DNA transposons are the mobile elements that move by a “cut and paste” mechanism (1, 2).

In contrast, retrotransposons encode reverse transcriptase, and move by a “copy and paste” mechanism. The process of retrotransposon insertion into genomic locations involves an RNA intermediate. Retrotransposons can be classified into long terminal repeat (LTR) and non-LTR by: where A refers to the peak area of the compound of interest (subscript i) and standard (subscript st) respectively, and f st is the response factor of the standard compound.

Usually, an arbitrary value (e.g. 1 or ) is assigned to f sing the relative molar responses and using n-alkanes as the standards, the assigned value of f st is usually the number of carbon atoms of the n.

Human cytomegalovirus (HCMV) gene expression during infection is characterized as a sequential process including immediate-early (IE), early (E), and late (L)-stage gene expression.

The most abundantly expressed gene at the IE stage of infection is the major IE (MIE) gene that produces IE1 and IE2. IE1 has been the focus of study because it is an important protein, not only for viral gene Cited by: 7.

Telomeres and brain tumors Brain tumors research is being performed worldwide at a remarkable pace, with some of the more recent promising studies focused on identification of aberrant genetic events and signalling pathways, tumor stem cell identification and characterization, modulation of tumor immunological responses, combination therapies Author: Domenico La Torre, Giovanni Raffa, Chiara Tomasello, M’Hammed Aguennouz, Antonino Germano.

Identification and characterization of the dermal Panniculus carnosus muscle stem cells. Stem Cell Reports Naldaiz-Gastesi N, Goicoechea M, Alonso-Martín S, Aiastui A, López-Mayorga M, García-Belda P, Lacalle J, San Jose C, Arauzo-Bravo M, Trouilh L, Le Berre V, Herrero D, Matheu A, Bernad A, García-Verdugo JM, Carvajal JJ, Relaix F, Lopez.

Using a two-element iAc/Ds transposon-tagging system, we identified a rice (Oryza sativa L. cv Nipponbare) recessive mutant, anther indehiscence1 (aid1), showing partial to complete spikelet sterility. Spikelets of the aid1 mutant could be classified into three types based on the viability of pollen grains and the extent of anther dehiscence.

Type 1 spikelets (approximately 25%) were Cited by:. Mammalian telomeres consist of TTAGGG repeats, telomeric repeat binding factor (TRF), and other proteins, resulting in a protective structure at chromosome ends. Although structure and function of Cited by: Cancer: New Insights for the Healthcare Professional: Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer.

The editors have built Cancer: New Insights for the Healthcare Professional: Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper Reviews: 1.Abstract.

Studies over many years have revealed the central importance of poly(ADP-ribose) metabolism in the maintenance of genomic integrity. While the involvement of poly(ADP-ribose) polymerase-1 (PARP-1) in this metabolism has been long known, more recent studies have demonstrated the contribution of many different genes coding for PARPs to promoting cellular Cited by: